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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Cell Signal. 2018 Feb 21;46:15–22. doi: 10.1016/j.cellsig.2018.02.009

Figure 1.

Figure 1

(A) A schematic illustration of SCFFBW7 E3 ubiquitin ligase complex. (B) Upstream FBW7 signaling that modulates FBW7 function, stability, and subcellular localization. FBW7 E3 ligase activity is coordinately controlled by phosphorylation, ubiquitination, and interaction with key regulatory proteins.