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Important mediators of erythropoiesis under different conditions.
| ERYTHROPOIESIS | ERYTHROID PATHWAYS | ERYTHROBLASTS | IRON METABOLISM |
RED BLOOD CELLS |
|---|---|---|---|---|
|
| ||||
| Steady-state | EPO-JAK2-STAT5 | BM progenitors | Hepcidin |
|
|
| ||||
| Stress | EPO-JAK2-STAT5 | Erythroid stress progenitors | ↓ Hepcidin |
|
| BMP4-SMAD5-SCF/cKIT | ||||
| GR-PPARalpha? | ||||
| Hedgehog | ||||
| Notch2 | ||||
| pIgA1/TFR-Erk/Akt | ||||
|
| ||||
| Anemia of Inflammation (iron-restricted) | EPO-JAK2-STAT5 | BM progenitors | Inflammation |
|
| ↑ Hepcidin | ||||
