Skip to main content
. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Cancer Res. 2018 Jan 31;78(7):1792–1804. doi: 10.1158/0008-5472.CAN-17-2774

Figure 7. Co-expression of p-EGFRY1173, TRIM59, and p-STAT3Y705 is correlated with a worse prognosis of gliomas.

Figure 7

A, In total, 107 GBM specimens were analyzed by IHC. Representative images of two GBM specimens that were IHC stained positive or negative by the indicated antibodies. Scale bars: 50 μm. B, Correlation of expression between p-EGFRY1173 and TRIM59, or TRIM59 and p-STAT3Y705. C, Kaplan-Meier analyses of patients with high p-EGFRY1173/high TRIM59-expressing tumors (red line) versus low EGFRY1173/low TRIM59-expressing tumors (black line), or high TRIM59/high p-STAT3Y705-expressing tumors (red line) versus low TRIM59/low p-STAT3Y705-expressing tumors (black line) based on IHC analyses in A. Median survival (in months) in left: low, 14.90; high, 9.53. Median survival (in months) in right: low, 14.51; high, 10.13. P values were calculated by the log-rank test. Black tick markers indicate censored data. D, A working model of EGFR/TRIM59/STAT3 signaling pathway in glioma tumorigenesis.