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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Cancer Prev Res (Phila). 2017 Dec 8;11(4):215–226. doi: 10.1158/1940-6207.CAPR-17-0296

Figure 4. The anti-inflammatory effects of pioglitazone are mediated by MCP-1.

Figure 4

A, study schema. Beginning at 6 weeks of age, wild-type and MCP-1 −/− (B6.129S4-Ccl2tm1Rol/J) mice were fed either low fat (LF) or high fat (HF) diets for 20 weeks. Other mice received 12 weeks of HF diet before being switched to HF diet containing 0.06% w/w pioglitazone for 8 weeks. All mice were sacrificed at 26 weeks of age. B, body weight was monitored weekly in different treatment groups. C, periprostatic white adipose inflammation was quantified as CLS/cm2. Mean ± SD (error bars) are shown; n=4–6/group; *p<0.05 compared with HF diet group.