Table 1.
Description of the GENUS Consortium Sample Collection.
| Acronym | Sample | Site | GWAS Array | Neuropsychological data | T1-weighted structural MRI data | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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| Patients (N) |
Controls (N) |
FHR (N) |
Male (%) |
Eur (%) |
Patients (N) |
Controls (N) |
FHR (N) |
Male (%) |
Eur (%) |
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| CAMH | Centre for Addiction and Mental Health | Toronto, Canada | Illumina OmniExpress | 123 | 144 | 0 | 56.2 | 76.1 | 89 | 115 | 0 | 55.4 | 76.5 |
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| CATIE | Clinical Antipsychotic Trials of Intervention Effectiveness | Multi-site, USA | Affymetrix 500K; Perlegen’s custom 164K chip | 741 | 0 | 0 | 73.6 | 54.7 | --- | --- | --- | --- | --- |
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| CIDAR/VA | Boston Center for Intervention Development and Applied Research/VA Healthcare System | Boston, USA | Illumina OmniExpress | 76 | 107 | 6 | 68.8 | 60.0 | 68 | 101 | 6 | 68.0 | 59.4 |
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| COGS-UK | Cognition and Genetics in Schizophrenia & Bipolar Disorder | Cardiff, UK | Illumina Infinium OmniExpressExome-8 | 835 | 0 | 0 | 58.8 | 97.3 | --- | --- | --- | --- | --- |
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| GAP | Genetics and Psychosis First – Episode Study | London, UK | Illumina HumanCore-24 Exome BeadChip | 164 | 160 | 0 | 59.6 | 46.8 | 132 | 94 | 0 | 56.2 | 35.0 |
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| IMH-SIGNRP | Institute of Mental Health – Singapore Imaging Genetics and Neuropsychological Research in Psychosis | Singapore | Illumina Human OmniZhongHua-8; Illumina Human1M-Duo; Affymetrix 6.0 | 150 | 63 | 0 | 55.9 | 0 | 243 | 81 | 0 | 62.4 | 0 |
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| IMH-STCRP | Institute of Mental Health – Singapore Translational and Clinical Research in Psychosis | Singapore | Illumina HumanOmniZhongHua-8 BeadChip | 420 | 1,012 | 0 | 52.9 | 0 | --- | --- | --- | --- | --- |
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| KCL-MFS | King’s College London – Maudsley Family Study | London, UK | Affymetrix 6.0 | 183 | 120 | 278 | 48.0 | 95.1 | --- | --- | --- | --- | --- |
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| KCL-MTS | King’s College London – Maudsley Twin Study | London, UK | Affymetrix 6.0 | 127 | 297 | 47 | 42.9 | 100 | 63 | 75 | 23 | 60.3 | 94.5 |
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| L&R | Language and Risk in Schizophrenia | Boston, USA | Illumina Infinium PsychArray* | 0 | 31 | 44 | 34.7 | 74.7 | 0 | 33 | 51 | 33.3 | 71.4 |
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| MCIC | Mind Clinical Imaging Consortium | Multi-site, USA | Illumina HumanOmni1-Quad BeadChip | 112 | 95 | 0 | 72.0 | 75.3 | 118 | 97 | 0 | 71.2 | 76.7 |
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| MGH | Massachusetts General Hospital | Boston, USA | Illumina Infinium PsychArray* | 434 | 0 | 0 | 72.4 | 68.8 | 61 | 123 | 0 | 65.2 | 73.2 |
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| NEFS | New England Family Study | Boston, USA | Illumina Infinium PsychArray* | 83 | 151 | 33 | 44.6 | 86.2 | 72 | 155 | 20 | 44.5 | 85.8 |
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| PAGES | Phenomics and Genomics Sample | Munich, Germany | Illumina OmniExpress; Illumina HumanHap300 | 210 | 1,341 | 0 | 50.0 | 99.6 | --- | --- | --- | --- | --- |
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| PHRS | Pittsburgh High Risk Study | Pittsburgh, USA | Illumina Infinium PsychArray* | 0 | 53 | 77 | 45.4 | 41.0 | 0 | 46 | 67 | 44.3 | 55.8 |
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| TCD/NUIG | Trinity College Dublin/National University of Ireland, Galway | Multi-site, Ireland | Affymetrix 6.0; Illumina HumanCore Exome | 904 | 290 | 0 | 60.9 | 99.9 | 175 | 312 | 0 | 56.9 | 99.8 |
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| UMCU-SZ1 | University Medical Center Utrecht – Schizophrenia Study 1 | Utrecht, Netherlands | Illumina HumanHap550; Illumina Infinium OmniExpressExome-8 | 97 | 143 | 0 | 68.3 | 98.6 | 159 | 157 | 0 | 69.3 | 99.1 |
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| UMCU-SZ2 | University Medical Center Utrecht – Schizophrenia Study 2 | Utrecht, Netherlands | Illumina HumanHap550; Affymetrix 6.0; Illumina Infinium OmniExpressExome-8 | 233 | 144 | 235 | 58.8 | 97.5 | 184 | 131 | 212 | 59.0 | 93.6 |
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| ZHH | Zucker Hillside Hospital | New York, USA | Illumina OmniExpress | 0 | 219 | 0 | 49.3 | 100 | --- | --- | --- | --- | --- |
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| TOTAL | 4,892 | 4,370 | 720 | 56.5 | 72.2 | 1,364 | 1,520 | 379 | 57.4 | 65.0 | |||
Data in this table are based on the total GENUS sample collection; data for the subset with genotype data are provided in Supplementary Table 1.
All samples with T1 MRI scans also have diffusion-weighted MRI scans except the PHRS, UMCU-SZ1, and UMCU-SZ2 samples.
Population ancestry determined from genetic data (where available) or self report.
Eur = European-derived ancestry; FHR = familial high-risk.
*
Samples genotyped at the central GENUS site.