Table 3.
Core neuropsychological tests available for GENUS Consortium samples.
| Attention/Processing Speed | Attention/Vigilance | Working Memory
– verbal |
Working Memory
– non-verbal |
Verbal Learning & Memory | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Sample |
Digit Symbol Coding |
TMT-A* |
Verbal Fluency |
CPT-IP* | Other |
Letter- Number Span |
Other |
Spatial Span |
Other |
Word
List Learning |
Story Recall |
Other |
| CAMH | RBANS | x* | RBANS Semantic/COWAT | UMD* | RBANS Digit Span | RBANS | RBANS | |||||
| CATIE | Category Instances/COWAT | x* | UMD* | SDRT | HVLT | |||||||
| CIDAR-VA | BACS* | x* | MCCB* | x* | ACPT | UMD* | WMS-III* | HVLT-R* | WMS-III or CMS | |||
| COGS-UK | BACS* | x* | MCCB* | x* | UMD* | WMS-III* | HVLT-R* | |||||
| GAP | WAIS-III | x* | Semantic/COWAT | WAIS-III Digit Span | WMS-III* | CANTAB SWM | WMS-III | |||||
| IMH-SIGNRP | BACS* | BACS Category Instances/COWAT | BACS Digit Sequencing | BACS | ||||||||
| IMH-STCRP | BACS* | BACS Category Instances | x* | BACS Digit Sequencing | BACS | |||||||
| KCL-MFS | WAIS-R | x* | CANTAB RVIP | WAIS-R/WMS-R Digit Span/Arithmetic | CANTAB SWM | WMS-R | WMS-R VerbPA | |||||
| KCL-MTS | WAIS-III-UK | x* | Semantic/COWAT | CANTAB RVIP | WAIS-III-UK | WAIS-III-UK Digit Span/Arithmetic | WMS-R-UK VisMem Span | CANTAB SWM | WMS-R-UK | WMS-R-UK VerbPA | ||
| L&R | BACS* | x* | MCCB* | x* | ACPT | UMD* | WMS-III* | HVLT-R* | WMS-III | |||
| MCIC | x* | D-KEFS Semantic/Phonemic | WAIS-III | HVLT-R* | WMS-III | |||||||
| MGH | WAIS-III | Semantic/COWAT | x* | WAIS-III | WAIS-III Digit Span/Arithmetic | CVLT | ||||||
| NEFS | WAIS-R | COWAT | ACPT | WAIS-R Digit Span | CVLT or CVLT-II | WMS-R or WMS-III | ||||||
| PAGES | WAIS-R-DE | x* | Semantic/Phonemic | 3–7 CPT | WAIS-R-DE Digit Span/Arithmetic | n-back | VLMT | WMS-R-DE | WMS-R-DE VerbPA | |||
| PHRS | MAE Semantic/Phonemic | x* | A-X CPT | Cogtest SWM | Cogtest | |||||||
| TCD/NUIG | x* | COWAT | x* | 1–9 CPT | WMS-III | CANTAB SWM/n-back | CVLT-SF | WMS-III | ||||
| UMCU-SZ1 | MAE Semantic/Phonemic | H-Q CPT | CVLT-I-NL | |||||||||
| UMCU-SZ2 | WAIS-III-NL | H-Q CPT | WAIS-III-NL Arithmetic | AVLT | ||||||||
| ZHH | BACS* | x* | MCCB*/COWAT | x* | UMD* | WAIS-R Digit Span | WMS-III* | n-back | HVLT-R* | |||
| N patients | 3,488 | 1,549 | 3,956 | 2,337 | 703 | 2,895 | 1,866 | 1,097 | 1,644 | 3,488 | 1,452 | 388 |
| N controls | 3,535 | 1,116 | 2,826 | 1,410 | 1,025 | 1,080 | 3,248 | 610 | 904 | 2,519 | 1,017 | 705 |
| N FHR | 396 | 196 | 280 | 119 | 381 | 79 | 347 | 76 | 89 | 384 | 82 | 177 |
| N total | 7,419 | 2,861 | 7,062 | 3,866 | 2,109 | 4,054 | 5,461 | 1,783 | 2,637 | 6,391 | 2,551 | 1,270 |
| Visual Learning & Memory | Reasoning/Problem Solving | Visuo-spatial Ability | Verbal Ability | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Sample | BVMT-R* | Other | TMT-B | WCST | Other | Block Design | Other | Vocabulary | Other |
| CAMH | RBANS Figure Recall | x | Stroop | RBANS JOLO/Figure Copy | |||||
| CATIE | 64-C | WISC-III Mazes | |||||||
| CIDAR-VA | BVMT-R* | 64-C | NAB Mazes* | WASI | WASI | D-KEFS Proverbs | |||
| COGS-UK | BVMT-R* | NAB Mazes* | |||||||
| GAP | WMS-III VisRep | x | CANTAB SOC | WAIS-III | WAIS-III MR | WAIS-III INF | |||
| IMH-SIGNRP | BACS TOL | ||||||||
| IMH-STCRP | 64-P | BACS TOL | WASI MR/Benton JOLO | ||||||
| KCL-MFS | WMS-R VisRep | x | CANTAB IDED | WAIS-R | WAIS-R OA/PA/PC | WAIS-R | WAIS-R COM/INF/SIM | ||
| KCL-MTS | WMS-R-UK VisRep/VisPA | x | CANTAB IDED | WAIS-III-UK | WAIS-III-UK OA/PA/PC | WAIS-III-UK | WAIS-III-UK COM/INF/SIM | ||
| L&R | BVMT-R* | 64-C | NAB Mazes* | WASI | WASI | D-KEFS Proverbs | |||
| MCIC | BVRT/WMS-III Faces | x | TOL | WAIS-III | WAIS-III | WAIS-III SIM | |||
| MGH | 128-C/64-C | WAIS-III | WAIS-III MR/OA/PA/PC | WAIS-III | WAIS-III COM/INF/SIM | ||||
| NEFS | WMS-III Faces/Rey CFT Recall | 128-P | Stroop | WAIS-R | WAIS-R PA/Rey CFT Copy | WAIS-R | WAIS-R COM/INF; RAN | ||
| PAGES | WMS-R-DE FigMem/VisRep/VisPA | x | 128-C | TOL-DE | WAIS-R-DE | WAIS-R-DE OA/PA/PC | WAIS-R-DE | WAIS-R-DE COM/INF/SIM | |
| PHRS | CNB VOLT | 128-P | Cogtest Go-No-Go | ||||||
| TCD/NUIG | WMS-III Faces/CANTAB PAL | x | CANTAB IDED/SART | WAIS-III-R-UK | WAIS-III-R-UK MR | WAIS-III-R-UK | WAIS-III-R-UK SIM | ||
| UMCU-SZ1 | Stroop | WAIS-III-R-NL | WAIS-III-R-NL PA | WAIS-III-R-NL | WAIS-III-R-NL COM | ||||
| UMCU-SZ2 | NAB Mazes*/RST | WAIS-III-NL | WAIS-III-NL INF | ||||||
| ZHH | BVMT-R* | x | 128-P | NAB Mazes*/Stroop | |||||
| N patients | 897 | 1,604 | 836 | 1,376 | 3,555 | 2,260 | 1,615 | 1,754 | 2,048 |
| N controls | 328 | 1,628 | 1,408 | 835 | 2,781 | 2,744 | 3,131 | 2,425 | 2,617 |
| N FHR | 48 | 317 | 145 | 134 | 350 | 522 | 33 | 285 | 567 |
| N total | 1,273 | 3,549 | 2,389 | 2,345 | 6,686 | 5,526 | 4,779 | 4,464 | 5,232 |
MATRICS test.
References for all neuropsychological tests are provided in the Supplemental Materials.
Data in this table are based on the total GENUS sample collection (genotyped plus ungenotyped).
Abbreviations: 128-P, 128-C = 128-card paper, computerized version; 64-P, 64-C = 64-card paper, computerized version; ACPT = Auditory CPT; AVLT = Auditory Verbal Learning Test; BACS = Brief Assessment of Cognition in Schizophrenia; BVMT-R= Brief Visuospatial Memory Test-Revised; BVRT = Benton Visual Retention Test; CANTAB = Cambridge Neuropsychological Test Automated Battery; CFT = Complex Figure Test; CMS = Children’s Memory Scale; CNB = Computerized Neurocognitive Battery; COWAT = Controlled Oral Word Association Test; CPT(-IP) = Continuous Performance Test (Identical Pairs); CVLT(-SF) = California Verbal Learning Test (Short Form); DE = German version; D-KEFS = Delis–Kaplan Executive Function System; FigMem = Figural Memory; HVLT = Hopkins Verbal Learning Test; IDED = Intra-Extra Dimensional Set Shifting; JOLO = Judgment of Line Orientation; MAE = Multilingual Aphasia Examination; MCCB = MATRICS Consensus Cognitive Battery; NAB = Neuropsychological Assessment Battery; NL = Dutch version; PAL = Paired Associates Learning; RAN = Rapid Automatized Naming; RBANS = Repeatable Battery for the Assessment of Neuropsychological Status; RST = Response Shifting Task; RVIP = Rapid Visual Information Processing; SART = Sustained Attention to Response Task; SDRT = Spatial Delayed Response Task; SOC = Stockings of Cambridge; SWM = Spatial Working Memory; TOL = Tower of London; TMT-A, B = Trail Making Test Part A, B; UK = British version; UMD = University of Maryland; VerbPA = Verbal Paired Associates; VisMemSpan = Visual Memory Span; VisPA = Visual Paired Associates; VisRep = Visual Reproduction; VLMT = Verbal Learning and Memory Test; VLT = Verbaler Lern Test; VOLT = Visual Object Learning Test; WAIS = Wechsler Adult Intelligence Scale (Subtests: COM = Comprehension; INF = Information; MR = Matrix Reasoning; OA = Object Assembly; PA = Picture Arrangement; PC = Picture Completion; SIM = Similarities); WASI = Wechsler Abbreviated Scale of Intelligence; WCST = Wisconsin Card Sorting Test; WISC = Wechsler Intelligence Scale for Children; WMS = Wechsler Memory Scale