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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Shock. 2018 Sep;50(3):339–345. doi: 10.1097/SHK.0000000000001012

Fig. 1. Stearoyl LPC inhibits intracellular LPS-induced caspase-11 activation and pyroptosis.

Fig. 1

Peritoneal macrophages were primed for 6 h with LPS (100ng/ml) or Pam3CSK4 (1μg/ml), then treated as indicated with LPC for 2 h. Cells were then treated for 16 h with LPS(1μg/ml), CTB (20μg/ml) or Dotap as indicated. (A, C, E) LDH release assay for cell death. (B, D, F) Western blotting against caspase-11 in the culture supernatants (sup) of cell cytosol (Cell-ext). Graphs show mean ± SD. Data are representative of at least two independent experiments.*P<0.05,**P<0.01.