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. 2018 Jan 24;92(4):1625–1638. doi: 10.1007/s00204-018-2162-7

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — Enzyme activity in the pooled hepatic fractions of BaP-treated WT, HRN and HBRN mice using either NADPH or NADH as the cofactor. a POR activity was measured as nmol of cytochrome c/mg/min and was detected only in microsomal fractions from WT mice. b Cyp1a enzyme activity was determined using the EROD assay with activity being expressed as pmol of resorufin/mg protein/min. c Cyp1a1 enzyme activity was determined by the oxidation of Sudan I to hydroxylated metabolites with activity being measured as nmol of total C-hydroxylated metabolites/mg protein/min. Values are given as mean ± SD (n = 3). ND not detected. Statistical analysis was performed by one-way ANOVA with Tukey’s multiple comparison test (*, compared to WT; #, compared to HRN. *P ≤ 0.05 **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001)