Fig. 5.
a Formation of BaP-7,8-dihydrodiol and dG-N2-BPDE (adduct 1) during in vitro incubations with hepatic microsomal fractions from BaP-pretreated WT, HRN and HBRN mice using either NADPH or NADH as cofactor. b Formation of 9-hydroxy-BaP and adduct 2 during in vitro incubations with hepatic microsomal fractions from BaP-pretreated WT, HRN and HBRN mice using either NADPH or NADH as cofactor. Values are given as mean ± SD (n = 3). ND not detected. Statistical analysis was performed by one-way ANOVA with Tukey’s multiple comparison test (*, compared to WT; #, compared to HRN. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001)