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. 2018 Mar 21;5(3):172155. doi: 10.1098/rsos.172155

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© 2018 The Authors.

Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 3. — Single PTX-induced channel activity. (a) Perfusion with solution containing 2 nM of PTX caused the channel to open, showing epochs with intense open/close transitions and epochs where the induced channel remains in the closed state. (b) Simulation of the activity of the PTX-induced channel. Representing the experimental procedure, the [PTX]o was maintained equal to 2 nM up to the channel opening until the pump changed to the substate PTXEo. (Left) Simulation of the most intense period of activity, associated with transitions between the substates PTXEc and PTXEo. (Right) Simulation of period where the pump remains in the closed substate PTXEc most of the time.