Fig. 5.

A single in vivo exposure to ethanol disrupts mOP-LTD at cortical inputs but not mOP-STD at thalamic inputs. a Representative light-evoked synaptic traces (oEPSC) from the DLS during baseline, immediately after DAMGO (0.3 μM, 5 min) application (14–19 min), and final 10 min of recording in saline (blue traces) and EtOH (red traces)-injected Ai32-Vglut2Cre+ mice. b, c EtOH does not affect peak inhibition (P = 0.96, t₁₃ = 0.05, saline n = 7 from 2 mice and EtOH n = 8 from 2 mice) or mOP-STD induced by DAMGO in the DLS (P = 0.824, t₁₃ = 0.227, saline n = 7 from 2 mice and EtOH n = 8 from 2 mice). d Representative oEPSC traces from DLS before and after DAMGO (0.3 μM, 5 min) application in saline (blue traces) and EtOH (red traces)-injected Ai32-Emx1Cre+ mice. e, f EtOH produces a disruption of mOP-LTD from cortical inputs induced by DAMGO (0.3 μM, 5 min) in the DLS (P = 0.016, t₁₄ = 2.75, saline n = 6 from 2 mice and EtOH n = 10 from 4 mice). Unpaired Student’s t test. *P < 0.05. Data represent mean ± SEM