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. 2018 Mar 28;9:611. doi: 10.3389/fimmu.2018.00611

Table 5.

Measurements of ER subtype mRNA and protein in freshly isolated systemic lupus erythematosus (SLE) T cells.

Samples ERɑ ERβ ERɑ ERβ Estradiol pg/ml


(mRNA) (Protein)
SLE-1 0.036 0.811 0.62 0.61 166.3
SLE-2 0 026 0.170 0.35 0.85 98.7
SLE-3 0.018 0.443 0.93 0.80 90.3
SLE-4 0.027 0.442 0.29 0.67 86.4
SLE-5 0.083 1.365 0.40 0.87 128.7
SLE-6 0.071 0.370 1.00 0.90 84.5
SLE-7 0.015 0.660 0.31 0.65 98.4
SLE-8 0 024 0.600 0.80 0.98 123.7
SLE-9 0.238 18.15 0.76 0.98 111.6

Median 0.027 0.60 0.62 0.85 98.7

Blood samples were drawn from SLE patients (n = 9) and T cells were purified by negative selection. ER subtype mRNA was measured by real-time PCR and protein in the same T cell sample was quantified by Western blotting. Plasma estradiol was measured at the time of blood draw. The levels of hormone in circulation were within the normal range for women with regular menstrual cycles.

SLEDAI, systemic lupus disease activity index.