Table 1.
Normalized pharmacokinetic parameters of topical ocular administration of PEA-NLC and PEA-suspension.
| Pharmacokinetics parameters |
|||||||
|---|---|---|---|---|---|---|---|
| PEA-NLC |
PEA-suspension |
||||||
| AUC (pmol⋅min/g) | tmax (min) | Cmax (pmol/g) | AUC (pmol⋅min/g) | tmax (min) | Cmax (pmol/g) | Basal [PEA] (pmol/g) | |
| Lens | ∗139639 ± 1532 | 30 | 2586 ± 485 | 27854 ± 2109 | 30 | 286 ± 135 | 409.6 ± 50.2 |
| Vitreous | ∗194673 ± 5957 | 180 | 5919 ± 541 | 5940 ± 567 | 180 | 138 ± 30 | 58.0 ± 4.7 |
| Retina | 22659 ± 786 | 180 | 315 ± 70 | – | – | – | 246.6 ± 28.8 |
∗p < 0.01 vs. PEA-suspension.