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. 2018 Mar 28;9:576. doi: 10.3389/fmicb.2018.00576

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Copyright © 2018 Riquelme-Barrios, Pereira-Montecinos, Valiente-Echeverría and Soto-Rifo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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m⁶A and its associated machinery. In the nucleus, the methyltransferase complex composed by METTL3 and METTL14 (other components were omitted for simplicity) methylates adenosines present in mRNA. This methyl group can be removed by one of the RNA demethylases ALKBH5 or FTO. Methylated mRNAs are recognized by YTHDC1 in the nucleus and by YTHDF1-3 or YTHDC2 in the cytoplasm. The presence of m⁶A also repeals RNA-binding proteins such as G3BP1-2, USP10 or CAPRIN1.