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. 2018 Apr 3;8:5478. doi: 10.1038/s41598-018-23304-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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BRL44408 (BRL) treatment reduces the contents of cardiac myeloperoxidase (MPO) and endothelial vascular cell adhesion molecule (VCAM)-1 in CLP-induced septic rats. The rats were administered either normal saline or BRL (1.5 mg/kg) 4 h after CLP or sham surgery. Whole-tissue lysates were prepared from the left ventricle at 20 h after CLP or sham surgery, and MPO (A) and VCAM-1 (B) concentrations within the myocardium were measured by Western blot analysis. GAPDH was used as loading control. n = 8 for each group. Statistical significance is shown as *P < 0.01. (C): Immunofluorescence staining of α_2A-AR (green) and CD31 (a positive marker for endothelial cells, red) in the left ventricle sections from the sham group at 6 h after sham surgery. DIC indicates differential interference contrast. Scale bar = 20 μm. (D): Immunofluorescence staining of VCAM-1 (green) and CD31 (red) in the left ventricle sections from septic rats at 6 h after the CLP challenge. DIC indicates differential interference contrast. Scale bar = 20 μm.