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. 2018 Apr 3;8:5478. doi: 10.1038/s41598-018-23304-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The effects of prazosin (PRAZ) or/and BRL44408 (BRL) on left ventricular and plasma TNF-α, left ventricular IκBα, p38 and JNK phosphorylation, caspase-3 activation as well as left ventricular myeloperoxidase (MPO) and VCAM-1 contents in CLP-treated rats. The rats received intraperitoneal injection with normal saline, BRL (1.5 mg/kg) or/and PRAZ (1.0 mg/kg) at 4 h after CLP or sham surgery. Plasma and whole-tissue lysates from the left ventricle were prepared at 20 h after CLP or sham surgery. Left ventricular (A) and plasma (B) TNF-α concentrations were detected by ELISA. Left ventricular IκBα (C), p38 (D) and JNK (E) phosphorylation, caspase-3 activation (F) as well as MPO (G) and VCAM-1 (H) were detected by Western blot assay. n = 7 for the sham or PRAZ group; n = 10 for the CLP, CLP+BRL, CLP+BRL+PRAZ and CLP+PRAZ groups. Statistical significance is shown as *P < 0.05.