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. 2018 Apr 3;8:5526. doi: 10.1038/s41598-018-23063-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Work Flow of Study. (A) Nasal airway genes were divided into those with sex-differential or variable X-chromosome methylation. (B) Histogram of the Matthews Correlation Coefficients shows a discernible cluster of X-linked genes above 0.995 (zoom on image). (C) Heatmap showing within-group similarity (clustering) of subjects (male or female) but not within term and preterm (n = 425 genes). Color key represents eigen-projections of each methylation pattern (per gene) on the PCA feature corresponding to the largest eigenvalue on the zero-mean, normalized methylation patterns.