Table 2.
X-linked genes with immune function and non-significant sex-based DNA methylation in the nasal airway of infants and children.
| Gene | Gene name | Xi status | Aec | Primary site |
|---|---|---|---|---|
| DDX3X | DEAD-box helicase 3, X-linked | Escape | Yes | Ubiquitous |
| PRKX | cAMP-dependent protein kinase catalytic subunit | Escape | Yes | Ubiquitous |
| TXLNG | Gamma-taxilin | Escape | Yes | Ubiquitous |
| L1CAM | Neural cell adhesion molecule L1 | Escape | Yes | Neurons, immune cells |
| VEGFD | Vascular endothelial growth factor D | Heterogeneous | Yes | Ubiquitous |
| TIMP1 | Metalloproteinase inhibitor 1 | Heterogeneous | Yes | Ubiquitous |
| TLR7 | Toll-like receptor 7 | Heterogeneous | Yes | Ubiquitous |
| BTK | Tyrosine-protein kinase BTK | Heterogeneous | N/A | Lymphocytes |
| BMP15 | Bone morphogenetic protein 15 | Heterogeneous | N/A | Testis |
| DDX53 | DEAD-box helicase 53, X-linked | Heterogeneous | N/A | Testis |
| AKAP4 | A-kinase anchor protein 4 | Heterogeneous | N/A | Cancer/Testis |
| SRPX2 | Sushi repeat-containing protein | Heterogeneous | N/A | Ubiquitous |
| GRPR | Gastrin-releasing peptide receptor | Heterogeneous | N/A | Ubiquitous |
| CD40LG | CD40 ligand | Heterogeneous | N/A | Ubiquitous |
| CTAG2 | Cancer/testis antigen 2 | Heterogeneous | N/A | Cancer/Testis |
| CXorf36 | Deleted in autism-related protein 1 | Heterogeneous | N/A | Neurons, ovary |
Genes listed according to X-inhibition (Xi) status, expression in airway epithelial cells (AEC) and primary site of expression/function. Genes in bold have prior evidence of escape Xi or heterogeneous X-chromosome methylation and reported expression in AEC.