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. 2018 Apr 3;8:5425. doi: 10.1038/s41598-018-23794-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Foxn1 overexpression in keratinocytes affects proteins that regulate the hypoxia/normoxia response. Schematic representation of molecular cross-talk between proteins exhibiting hypoxic or normoxic characteristics, according to proteome profiling results, and induced in keratinocytes transfected with Ad-Foxn1 (black colour) or Ad-GFP (control; white colour) (a). Grey colour indicates proteins that were not detected in the analysis but link identified proteins (a). Foxn1 mRNA expression in primary cultures of B6 keratinocytes (b) and Ad-Foxn1 or Ad-GFP (control)-transfected nude keratinocytes (c) cultured under normoxic (21% O₂) or hypoxic (1% O₂) conditions. Corresponding Mmp-9 mRNA (d) and Mmp-9 protein (f) expression in keratinocytes isolated from B6 mice and Mmp-9 mRNA (e) and Mmp-9 protein (g) expression in nude keratinocytes transfected with Ad-Foxn1 or Ad-GFP (control) cultured under normoxic (21% O₂) or hypoxic (1% O₂) conditions. Values are the mean ± SD; **p < 0.01, ***p < 0.001, ****p < 0.0001; m – molecular size marker.