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. 2018 Apr 3;8:5560. doi: 10.1038/s41598-018-21755-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Electrophysiological characterization of primary neurons on glass, cross-linked SU8-2 and chromium test-substrates. (a) Plot of mean resting membrane potential (RMP, ϕ) versus substrate material, indicating a significantly higher mean RMP for neurons grown on chromium (ϕ = −58.79 ± 2.99 mV, N = 14) than either glass (ϕ = −52.33 ± 5.3 mV, N = 21) or SU82 (ϕ = −49.81 ± 7.81 mV, N = 21). Statistical analysis was carried out using two-way ANOVA followed by Bonferroni’s multiple comparison test. (b) Representative traces of elicited action potential versus time, recorded under current clamp conditions using a sequence of 500 ms current pulses, increasing from 0 to 375 pA with a step-size of 25 pA. (c) Bar charts showing for each substrate material the mean firing rate versus current pulse amplitude, indicating a higher action potential firing threshold for neurons grown on chromium but no significant differences in the firing rates between substrates.