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. 2018 Mar 28;9:286. doi: 10.3389/fphar.2018.00286

Figure 3.

Figure 3

The effect of sodium nitrite administration on CI-dependent basal (State 2) respiration, on OXPHOS capacity and capacity of OXPHOS inhibition (State 4), as well as on the respiratory control ratio (RCR), the uncoupling of ETS and the P/E coupling ratio. There were no significant differences in the basal respiration between the examined groups. In dogs subjected to ischaemia and reperfusion (I/R), the CI-dependent OXPHOS and the ETS were significantly reduced, whereas the RCR was also, but not significantly, decreased. In these dogs the P/E coupling ratio did not differ from the SC dogs. Nitrite itself significantly reduced OXPHOS, ETS and RCR, without substantially modifying State 4 respiration and the P/E coupling ratio, compared with the SC dogs. In the nitrite treated dogs, subjected to I/R, there were further significant decreases in OXPHOS and RCR, and an increase in State 4 respiration, compared with the IC dogs. Since in these dogs ETS slightly increased compared with the IC dogs, the P/E coupling ratio was markedly reduced. Values are means ± S.E.M. from n = 5 animals/group. Values for each n were calculated from three replicates. *P < 0.05 compared with SC; #P < 0.05 compared with IC, §P < 0.05 compared with nitrite alone.