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. 2018 Mar 28;9:286. doi: 10.3389/fphar.2018.00286

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Copyright © 2018 Demeter-Haludka, Kovács, Petrus, Patai, Muntean, Siklós and Végh.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of sodium nitrite on CII-dependent basal (State 2) respiration, on OXPHOS capacity and capacity of OXPHOS inhibition (State 4), as well as on the respiratory control ratio (RCR), the uncoupling of ETS and the P/E coupling ratio. There were no significant differences between groups as regards the basal (State 2) respiration. In dogs subjected to ischaemia and reperfusion (I/R) no significant alterations occurred in the CII-dependent respiratory parameters. The administration of nitrite affected only the OXPHOS, which further reduced when the nitrite treated dogs had been subjected to I/R. In these dogs the CII-dependent RCR and P/E were also significantly decreased compared to the IC dogs. Values are means ± S.E.M. from n = 5 animals/group. Values for each n were calculated from three replicates.^*P < 0.05 compared with SC; ^#P < 0.05 compared with IC, ^§P < 0.05 compared with nitrite alone.