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. 2018 Mar 28;12:200. doi: 10.3389/fnins.2018.00200

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Copyright © 2018 Vetreno, Lawrimore, Rowsey and Crews.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Adolescent intermittent ethanol (AIE) treatment upregulated expression of Toll-like receptor (TLR) genes in the adult hippocampus. Quantitative PCR assessment of TLR mRNA in adult (P80) hippocampal tissue samples revealed an approximate 3-fold increase of TLR1, TLR5, and TLR8, an approximate 2.5-fold increase of TLR4 and TLR6, an approximate 2-fold increase of TLR2, and an approximate 50% increase of TLR7, relative to CONs. We did not observe an effect of AIE on mRNA levels of TLR3 or TLR9. qPCR analyses were run in triplicate. Data are presented as mean ± SEM. ^*p < 0.05, ^**p < 0.01 relative to CON.