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. 2018 Mar 28;12:200. doi: 10.3389/fnins.2018.00200

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Copyright © 2018 Vetreno, Lawrimore, Rowsey and Crews.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Running wheel exposure prevented the adolescent intermittent ethanol (AIE)-induced increase of the cell death marker cleaved caspase 3 in the adult hippocampal dentate gyrus. Modified unbiased stereological quantification revealed a 34% (±5%) increase of cleaved caspase 3+IR cells in the adult (P80) hippocampal dentate gyrus of AIE-treated animals, relative to CONs. Voluntary wheel running from P24 to P80 prevented the AIE-induced increase of cleaved caspase 3+IR cells, relative to AIE animals. Representative photomicrographs of cleaved caspase 3+IR cells in the adult hippocampal dentate gyrus from CON- and AIE-treated animals across exercise conditions. Scale bar = 50 μm. Data are presented as mean ± SEM. ^**p < 0.01.