Figure 6.

Voluntary wheel running prevented the adolescent intermittent ethanol (AIE)-induced phosphorylation of the proinflammatory transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells p65 (phosphorylated [pNF-κB p65]) in the adult hippocampal dentate gyrus. Modified unbiased stereological quantification of pNF-κB p65+IR cells revealed a 40% (±12%) increase in the adult (P80) hippocampal dentate gyrus of AIE-treated animals, relative to CONs. Interestingly, subjects in the AIE treatment group that were exposed to voluntary wheel running from P24 to P80 did not evidence the observed increase of pNF-κB p65+IR cells, relative to AIE animals. Representative photomicrographs of pNF-κB p65+IR cells in the adult hippocampal dentate gyrus from CON- and AIE-treated animals across exercise conditions. Scale bar = 100 μm. Data are presented as mean ± SEM. ^**p < 0.01.