Table 2.
Overall and sensitivity analyses of miR-146a C>G (rs2910164) and risk of IS.
| Genetic model | Subgroup | No. of studies | Meta-analysis | P for Egger's test | Heterogeneity | ||
|---|---|---|---|---|---|---|---|
| OR (95%CI) | P-value | I2 (%) | P-value | ||||
| G vs. C | Overall | 5 | 0.99 (0.87–1.12) | 0.87 | 0.77 | 60.1 | 0.04 |
| HWE-Yes | 4 | 0.99 (0.82–1.19) | 0.88 | 69.8 | 0.02 | ||
| GG vs. CC | Overall | 5 | 0.99 (0.74–1.31) | 0.92 | 0.85 | 61.4 | 0.04 |
| HWE-Yes | 4 | 0.98 (0.65–1.48) | 0.94 | 70.8 | 0.02 | ||
| CG vs. CC | Overall | 5 | 0.99 (0.88–1.11) | 0.85 | 0.50 | 0 | 0.46 |
| HWE-Yes | 4 | 1.01 (0.86–1.18) | 0.93 | 13.7 | 0.32 | ||
| CG + GG vs. CC | Overall | 5 | 0.99 (0.89–1.11) | 0.87 | 0.31 | 39.3 | 0.16 |
| HWE-Yes | 4 | 0.99 (0.80–1.23) | 0.94 | 53.5 | 0.09 | ||
| GG vs. CG + CC | Overall | 5 | 0.99 (0.79–1.24) | 0.94 | 0.85 | 50.2 | 0.09 |
| HWE-Yes | 4 | 0.99 (0.71–1.37) | 0.94 | 62.6 | 0.05 | ||
OR, odds ratio; CI, confidence interval; HWE, Hardy-Weinberg equilibrium.