Figure 1.

Experimental scheme. Wistar female rats were fed a balanced C-diet (18, 23, and 59% of the energy content derived from lipids, proteins and carbohydrates, respectively) or unbalanced HF-diet (46, 16, and 38% of the energy content derived from lipids, proteins, and carbohydrates, respectively) during the whole perinatal period, from day 1 of gestation up till postnatal week 4. Pups were weaned on the C-diet. Adults of 4.5 months were either maintained on the C-diet or shifted to the HF-diet for 10 weeks. Animals were euthanazied at the age of 7-months after a 14–16-h overnight fasting. Groups were named according to their respective perinatal and adult diets, i.e., C-C, C-HF, HF-C, and HF-HF.