Figure 8.

miRNA differential expression in groups HF-C or HF-HF vs. C-C. miRNAs and Partner-miRNAs specified by the genes miR-323,−3585,−433,−485, and−770 as well as the miRNA miR-547-3p appeared significantly impacted by the sole perinatal unbalanced environment (padj-value < 5.2E-02; see Table 3). For each of these miRNAs, the Fold-Change of Expression (FCE) in Groups HF-HF vs. C-C was plotted against the FCE in Groups HF-C vs. C-C. Both FCEs displayed high correlation (R² = 0.98) indicating that the 11 miRNAs defined a subset of miRNAs repeatedly impacted by the perinatal unbalanced environment.