Table 4.
miRNA expression in groups HF-C and HF-HF.
| miRNAs Differentially Expressed Between | ||||
|---|---|---|---|---|
| miRNA | Groups C-C and HF-C | Groups C-C and HF-HF | ||
| miRNA | FCE | Padj-value | FCE | Padj-value |
| miR-323-3p | 0.5 | 1.1E-02 | 0.4 | 5.3E-03 |
| miR-323-5p | 0.5 | 6.5E-03 | 0.7 | 5.3E-03 |
| miR-3585-3p | 3.4 | 3.1E-02 | 3.2 | 2.4E-02 |
| miR-3585-5p | 4.8 | 9.3E-03 | 4.6 | 2.3E-02 |
| miR-433-3p | 0.6 | 1.0E-02 | 0.6 | 2.0E-03 |
| miR-433-5p | 0.6 | 4.7E-02 | 0.5 | 1.7E-02 |
| miR-485-3p | 0.6 | 1.8E-03 | 0.5 | 5.1E-04 |
| miR-485-5p | 0.8 | 4.2E-02 | 0.8 | 2.2E-02 |
| miR-543-3p | 0.8 | 6.9E-03 | 0.5 | 1.7E-05 |
| miR-543-5p | 0.6 | 2.2E-02 | 1.0 | 4.2E-01 |
| miR-547-3p | 3.3 | 5.0E-02 | 3.6 | 5.2E-02 |
| miR-770-3p | 0.6 | 1.0E-02 | 0.5 | 5.3E-03 |
| miR-770-5p | 0.6 | 1.2E-02 | 0.7 | 1.1E-02 |
Thirteen miRNAs, i.e., the two strands specified by the genes miR-323, −3585, −433, −485, −543, and −770 as well as the miR-547-3p strand were differently expressed in groups HF-C vs. CC (see Table 3). Remarkably all these miRNAs except miR-543-5p (shaded miRNA) also displayed significant changes of expression (padj-value = < 5.2E-02) between groups C-C and HF-HF, thus defining a subset of miRNAs repeatedly impacted by the perinatal unbalanced environment. miRNAs are listed by alphabetical order.