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. 2018 Apr 3;8:5510. doi: 10.1038/s41598-018-22852-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CHBP inhibited TRPM7-like currents in TCMK-1 cells. The voltage ramp protocol invoking TRPM7 currents and the representative TRPM7 currents recorded in TCMK-1 cells (a). Time-dependent running up of TRPM7-like currents after break-in when dialyzed with Mg²⁺ free internal solution by whole cell patch clamp (b). Blockade of TRPM7-like current (at +100 mV) by CHBP (100 nmol/l) (c). The periods of exposure to the normal extracellular solutions and CHBP were indicated by horizontal bars. Outward TRPM7-like currents were inhibited by CHBP, but reversibly changed by CHBP washout. (n = 6, (d)).