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. 2018 Apr 3;8:5510. doi: 10.1038/s41598-018-22852-2

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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TRMP7 siRNA and inhibitor reduced inflammation and apoptosis inTCMK-1 cells. The protein expression of TRPM7, HMGB1, 32, 17 and 12 kDa caspase-3, Bax and Bcl-2 in the HR TCMK-1 cells was detected by western blotting (a). TRPM7 siRNA significantly reversed increased TRPM7, HMGB1, 32 and 17 kDa caspase-3 and Bax/Bcl-2 ratio, but not 12 kDa caspase-3 upon HR (b). Apoptotic cells were labelled by Annexin V/PI and quantitatively assessed by flow cytometer (c,e). The histograms showed that the increase of early apoptotic cells was inhibited by TRPM7 siRNA and its inhibitor 2-APB (n = 3, (d,f)).