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. 2018 Mar 28;9:297. doi: 10.3389/fphys.2018.00297

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Copyright © 2018 Sun, Liu, Zhang, Jiao, Tan, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of β-arrestin1 overexpression on Ang II-induced cardiovascular effects in the RVLM. (A), Original tracings of BP, HR, and integrated RSNA (Inte-RSNA) in response to Ang II injection into the RVLM in SHR pretreated with or without β-arrestin1 overexpression. (B), Percent changes in MAP (a) and Inte-RSNA (b) in response to Ang II injection after β-arrestin1 overexpression. Baseline levels of MAP in four groups before aCSF or Ang II injection are: AAV-GFP+aCSF:161 ± 4.02 mmHg; AAV-arrb1-aCSF:131 ± 4.67 mmHg; AAV-GFP+ Ang II 162 ± 4.26; AAV-arrb1-AngII 131 ± 5.12 mmHg. n = 5 per group. ^*P < 0.05 vs. AAV-GFP+aCSF group; ^#P < 0.05 vs. AAV-GFP+Ang II group.