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. 2018 Apr 3;8:5498. doi: 10.1038/s41598-018-23539-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of anti-IL-23R monoclonal antibodies on CIM. (A) Preventive treatment of WT mice with CIM with control antibodies (control) and anti-IL-23R monoclonal antibodies (anti IL-23R). The antibodies (1.0 mg/mouse) were administrated intraperitoneally a day before and 6 days after the immunization. The incidences of CIM in the two groups were 100% and 0%, respectively. (B) Therapeutic treatment of WT mice with CIM with the same dose of the antibodies 7 and 11 days after the immunization. The severity of CIM was evaluated histologically 14 days after the immunization. The incidences of CIM in the two groups were 83% and 28%, respectively. The results are representative of 2 independent experiments. Bars show the mean of the histological scores. Asterisks represent statistically significant differences (p < 0.05).