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. 2018 Apr 3;8:5446. doi: 10.1038/s41598-018-23571-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Diversity plots for microbiota patient samples. (A) Shannon and Simpson diversity indices calculated based on OTU analysis for each type of patient at M0 and M3. Shannon index for NR is significantly different than for R at M0 (two-tailed t-test with unequal variance, p-value = 0.04). (B) PCoA plot of β-diversity calculated by weighted UniFrac distances on OTU occurrence table. Left graph is coloured by the date of the sample. Timepoints M0 and M3 do not form separate clusters (ANOSIM, R = −0.011, p-value 0.641). Right plot is colored by the type of patient’s response (partial responders are removed for clarity). Patients with different level of response form significant clusters (ANOSIM, R = 0.1032, p-value 0.042).