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. 2018 Apr 3;8:5575. doi: 10.1038/s41598-018-23881-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hypothetical scheme representing how TGF-ß1 and IFN-γ affect the chemokine expression and subsequent monocyte migration of cardiac fibroblasts. The Figure illustrates the transdifferentiation process of fibroblasts towards myofibroblasts under TGF-ß1 and TGF-ß1 + IFN-γ conditions. Depending on the stimulus, the specific chemokine profile (CCL2, CCL7, and Cx3CL1) of the myofibroblasts results in a more pronounced attraction of Ly6C^low monocytes (TGF-ß1 stimulation) or of Ly6C^high monocytes (TGF-ß1 + IFN-γ stimulation). The Figure uses elements previously published by Van Linthout et al.² Stands for Ly6C.

Inline graphic — Hypothetical scheme representing how TGF-ß1 and IFN-γ affect the chemokine expression and subsequent monocyte migration of cardiac fibroblasts. The Figure illustrates the transdifferentiation process of fibroblasts towards myofibroblasts under TGF-ß1 and TGF-ß1 + IFN-γ conditions. Depending on the stimulus, the specific chemokine profile (CCL2, CCL7, and Cx3CL1) of the myofibroblasts results in a more pronounced attraction of Ly6C^low monocytes (TGF-ß1 stimulation) or of Ly6C^high monocytes (TGF-ß1 + IFN-γ stimulation). The Figure uses elements previously published by Van Linthout et al.² Stands for Ly6C.