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. 2018 Apr 3;8:5534. doi: 10.1038/s41598-018-23863-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Plasma Metabolic differences between FLT3-ITD and FLT3-WT AML. (A) PCA plots of plasma samples. Unbiased multivariate analysis does not show clear separation of samples based on FLT3 status groups. (B) PLSDA plot of plasma samples shows global separation of pediatric AML patients by FLT3 status (FLT3-ITD n = 8 and FLT3-WT n = 8, all samples were run in duplicate). (C) Heatmap shows relative abundance patterns of 209 plasma metabolites (known and un-annotated) with significantly differential abundance according to FLT3 status. Clustering within the heatmap shows a clear distinction of several metabolites between in FLT-WT and FLT3-ITD patients. (D) Heatmap of the global metabolome for patient plasma samples from AML patients.