Table 3.
Metabolites with significantly differential abundance in leukemia cell samples from patients with FLT3-ITD vs. without FLT3-ITD.
| Metabolite | Classification | Associated Pathway | p-value | FDR | Fold Change |
|---|---|---|---|---|---|
| Xylenesulfonate | Organic Acids | N/A | 1.09E-06 | 0.0005 | 0.8515 |
| Succinate | Organic Acids | TCA Cycle; Alanine, aspartate, and glutamate metabolism; Propanoate Metabolism; Tyrosine Metabolism; Butanoate metabolism; Phenylalanine metabolism; Glyoxlyate and dicarboxylate metabolism | 1.61E-06 | 0.0005 | 0.8708 |
| Disaccharide-6C/6 C | Sugars | N/A | 1.79E-06 | 0.0005 | 0.7703 |
| L-Acetylcarnitine | Amino Acids | Fatty Acid Metabolism | 2.35E-06 | 0.0005 | 3.7810 |
| Glyceraldehyde/Lactate | Aldehydes | Glycolysis or Gluconeogenesis; Pyruvate Metabolism; Propanoate metabolism | 3.70E-06 | 0.0007 | 0.8751 |
| Glucose/Fructose | Sugars | Starch and sucrose metabolism; Galactose Metabolism; Pentose Phosphate Pathway; Amino sugar and nucleotide sugar metabolism | 5.37E-06 | 0.0008 | 0.8398 |
| Inosine | Nucleosides | Purine metabolism | 1.87E-05 | 0.0018 | 2.2740 |
| Adenosine 5′-Monophosphate | Nucleosides | Purine metabolism; Nitrogen metabolism | 3.40E-05 | 0.0028 | 3.0967 |
| Allopurinol | Xenobiotics | N/A | 4.26E-05 | 0.0032 | 2.0377 |
| Guanosine | Nucleosides | Purine metabolism/biosynthesis | 5.29E-05 | 0.0037 | 1.9649 |
| Hypoxanthine | Nucleosides | Purine metabolism/biosynthesis | 1.27E-04 | 0.0060 | 2.7834 |
| Adenosine | Nucleosides | Purine metabolism/biosynthesis | 1.36E-04 | 0.0061 | 2.1136 |
| LysoPE(p-526.2933–12.92; 22:6) | Lipids | Lysophospholipid Metabolism | 2.18E-04 | 0.0084 | 85.5160 |
| Tryptophan | Amino Acids | Tryptophan Metabolism, Nitrogen metabolism, Aminoacyl-tRNA metabolism | 6.26E-04 | 0.0184 | 0.9078 |
| LysoPE(n-500.2768-12.71; 20:4) | Lipids | Lysophospholipid Metabolism | 6.51E-04 | 0.0184 | 0.9160 |
| Benzoate | Organic Acids | N/A | 8.50E-04 | 0.0199 | 0.9075 |
| Formyl-5-hydroxykynurenamine | Organic Acids | Tryptophan Metabolism | 1.23E-03 | 0.0238 | 0.6343 |
| LysoPE(n-452.2772-13.35; 16:0) | Lipids | Lysophospholipid Metabolism | 1.28E-03 | 0.0238 | 0.9064 |
| C6H12O6-HEXOSE/KETOSE/INOSITOL | Sugars | Galactose Metabolism; Amino sugar and nucleotide sugar metabolism | 1.50E-03 | 0.0250 | 0.9202 |
| L-Carnitine | Amino Acids | Fatty Acid Metabolism | 1.59E-03 | 0.0260 | 1.9458 |
| LL-2,6-Diaminoheptanedioate | Amino Acids | Lysine Biosynthesis | 1.70E-03 | 0.0268 | 3.2397 |
| L-leucyl-L-proline | Dipeptides | N/A | 1.77E-03 | 0.0274 | 1.6180 |
| LysoPE(p-502.2908-12.90: 20:4) | Lipids | Lysophospholipid Metabolism | 1.94E-03 | 0.0284 | 20.0570 |
| Arachidonic Acid (20:4) | Fatty Acids | Arachidonic acid metabolism | 2.77E-03 | 0.0339 | 0.8431 |
| 4-oxoproline | Amino Acids | Arginine and proline metabolism | 3.63E-03 | 0.0382 | 2.1616 |
| Glycodeoxycholic acid | Organic Acids | N/A | 3.94E-03 | 0.0395 | 0.9135 |
| Palmitoleic acid | Lipids | Fatty Acid Biosynthesis | 4.07E-03 | 0.0400 | 1.6714 |
| Citramalate | Fatty Acids | N/A | 4.30E-03 | 0.0417 | 0.8111 |
| LysoPE(n-480.3097-14.59: 18:0) | Lipids | Lysophospholipid Metabolism | 5.05E-03 | 0.0452 | 0.8803 |
| Guanine | Nucleosides | Purine metabolism/biosynthesis | 5.27E-03 | 0.0466 | 3.3509 |
| L-Methionine | Amino Acids | Aminoacyl-tRNA biosynthesis; Cysteine and methionine metabolism | 5.71E-03 | 0.0484 | 2.0903 |
| Leucine | Amino Acids | Aminoacyl-tRNA biosynthesis; valine, leucine, and isoleucine biosynthesis and degradation | 5.76E-03 | 0.0484 | 1.9154 |
| 2-alpha-D-glucosyl-D-glucose | sugars/lipids | N/A | 5.78E-03 | 0.0484 | 0.9215 |
Note: Metabolites with lower abundance in FLT3-ITD are in italics.