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. 2018 Apr 3;8:5466. doi: 10.1038/s41598-018-23889-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Treatment of B16-F10 metastatic melanoma tumor-bearing C57BL6 mice with RIT delivered by ²¹³Bi-8C3, immunotherapy with anti-CTLA4 mAb 9D9 and their combination. (A) treatment schematic; (B) treatment results. RIT alone and combination treatment groups received IP 150 μCi ²¹³Bi-8C3; immunotherapy alone and combination treatment groups received IP 100 μg 9D9 mAb on days 5, 9 and 11 after cell injection. Both the RIT and RIT plus immunotherapy groups showed significantly fewer lung metastases in comparison with the untreated control group (p = 0.045). No statistical difference between the efficacy of RIT alone and the combination of RIT plus immunotherapy groups was observed (p = 0.956).