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. 2018 Apr 3;8:5420. doi: 10.1038/s41598-018-23833-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Formation of tumor spheroids in the presence of powdered bone extract (10 and 100 µg/mL), collagen (5 and 10 µg/mL), and hydroxyapatite (5 and 10 µg/mL) after 24 h. An asterisk (*) denotes p < 0.05 compared with control. (A) Tumor spheroids with primary breast cancer cells. (B & C) Roughness and cross-sectional area of primary cell spheroids, respectively. (D) Tumor spheroids with TMD and BMD cells. (E & F) Roughness and area of TMD cell spheroids. (G & H) Roughness and cross-sectional area of BMD cell spheroids.