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. 2018 Apr 3;8:5420. doi: 10.1038/s41598-018-23833-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Temporal changes in the co-cultured tumor and bone spheroids. Of note, MC = MC3T3 osteoblast-like cells, and A5 = MLO-A5 osteocyte-like cells. (A & B) Shape changes by spheroid fusion of TMD or BMD tumor spheroids with MC3T3, MLO-A5, or MLO-Y4 bone spheroids. (C & D) Changes in the cross-sectional area of TMD and BMD spheroids, respectively. (E) Changes in the cross-sectional area of TMD spheroids (green). Control = no treatment, A5 fusion = fusion with MLO-A5 spheroid (red), and A5 media = culture in conditioned medium isolated from MLO-A5 osteocyte-like cells. (F) Shrinkage of E0771 spheroids by MLO-Y4 conditioned medium.