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. 2018 Apr 3;8:5424. doi: 10.1038/s41598-018-23631-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A,B) View of three-dimensional distribution of the mean values of stereological capillary parameters of KO (magenta, red, yellow) and WT mice (blue, dark green, green) in the capillary length (y-axis), volume (z-axis) and surface area (x-axis) of absolute capillary parameters (A) and relative capillary parameters (B, snapshot of the Suppl. Movie) at the age of 40 (triangles, magenta/blue), 60 (quadrangle, red/dark green) and 87 (dot, yellow/green) weeks. (C) mRNA expression of inflammation markers in testis of KO compared to WT revealed by qRT-PCR studies. *p < 0.05.