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. 2018 Apr 3;8:5424. doi: 10.1038/s41598-018-23631-9

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A–D) Leydig cell number (A and B) and size (C and D) in KO and WT mice analyzed by stereological investigations on semithin sections. (A,C) Leydig cell number (A) and size (C) of data from pooled age groups (20, 40, 60, 87 weeks). (B,D) Leydig cell number (B) and size (D) from the individual age groups. *p < 0.05, **p < 0.01, ***p < 0.001. KO raw data; WT raw data; KO median; WT median. highest value still within 1.5 times the interquartile range of the third quartile of KO. highest value still within 1.5 times the interquartile range of the third quartile of WT. lowest value still within 1.5 times the interquartile range of the first quartile of KO. lowest value still within 1.5 times the interquartile range of the first quartile of WT. values between first and third quartile of KO data (indicating the middle 50% and the interquartile range). values between first and third quartile of WT data (indicating the middle 50% and the interquartile range). (E) Histological images of the testicular interstitial tissue of the different age groups in WT and KO mice (examples of Leydig cells are encircled in red).

Inline graphic — (A–D) Leydig cell number (A and B) and size (C and D) in KO and WT mice analyzed by stereological investigations on semithin sections. (A,C) Leydig cell number (A) and size (C) of data from pooled age groups (20, 40, 60, 87 weeks). (B,D) Leydig cell number (B) and size (D) from the individual age groups. *p < 0.05, **p < 0.01, ***p < 0.001. KO raw data; WT raw data; KO median; WT median. highest value still within 1.5 times the interquartile range of the third quartile of KO. highest value still within 1.5 times the interquartile range of the third quartile of WT. lowest value still within 1.5 times the interquartile range of the first quartile of KO. lowest value still within 1.5 times the interquartile range of the first quartile of WT. values between first and third quartile of KO data (indicating the middle 50% and the interquartile range). values between first and third quartile of WT data (indicating the middle 50% and the interquartile range). (E) Histological images of the testicular interstitial tissue of the different age groups in WT and KO mice (examples of Leydig cells are encircled in red).