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. 2018 Apr 3;8:5413. doi: 10.1038/s41598-018-23496-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of doxorubicin and β-cholanic acid on glutathione levels in buthionine-treated MCF-7 cells. MCF-7_CC12 cells (a) and resistant MCF-7_DOX2-12 cells (b) were treated simultaneously with buthionine sulfoximine (50 μM for 1 h) followed by combinations of doxorubicin (2 μM) and β-cholanic acid (200 uM) for assessment of their glutathione levels. Treatment with β-cholanic acid in MCF-7_DOX2-12 cells resulted in elevated cellular glutathione levels. All data were standardized to respective untreated controls. Experiments were performed in triplicate. Statistical analyses were conducted using an ANOVA with a post-hoc Bonferoni correction.