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. 2018 Apr 3;8:5413. doi: 10.1038/s41598-018-23496-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of bile salts on sensitivity of human tumour cell lines to doxorubicin as measured using clonogenic assays. Cell lines used included MCF-7_CC12, MCF-7_DOX2-12, H69, H69_AR, HEK293 and HEK293_MRP1 cells. (a–c). Survival curves for MCF-7, H69 and HEK293 cells (and their doxorubicin-resistant counterparts) treated with increasing concentrations of doxorubicin in the presence or absence of 200 μM β-cholanic acid. (d,e). Doxorubicin sensitivity curves for MCF-7 and HEK293 cells as a function of doxorubicin concentration in the absence or presence of 200 μM deoxycholic acid. (f). Effect of MK571 on doxorubicin sensitivity in wildtype and doxorubicin-resistant MCF-7 cells. (g–i) Summary of IC50 values for doxorubicin for various cell lines under various conditions. *** p < 0.001 as determined by an ANOVA with a Bonferoni correction.