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. 2018 Apr 3;8:5482. doi: 10.1038/s41598-018-23856-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Trooper mice harbour an intronic point mutation in Chd7. (A) 20 F₁N₁ mice were classified as hearing impaired following click-ABR testing (threshold ≥45 dB SPL). SNP Haplotypes for the proximal region of chromosome 4 are illustrated, with the numbers below each haplotype representing the number of mice observed with that haplotype. The region between the centromere and rs13477553 was heterozygous in all hearing impaired mice. (B) DNA sequence electropherograms of a region of Chd7 intron 9 in two hearing impaired Trooper mice and an unaffected littermate. Both affected mice were heterozygous for a c.3219-18T> A mutation in Chd7, which was predicted to affect splicing.