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. 2018 Apr 3;8:5428. doi: 10.1038/s41598-018-23684-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The bipolar morphology is mechanosensitive. (a) Platelets were seeded for 60 min on FG that was covalently crosslinked on polyacrylamide (PAA) hydrogels of different stiffness. Schematic not to scale. (b) Overview images (top), adhesion morphology plots (middle) and representative cells (bottom) of platelets on 2.0 kPa, 4.5 kPa, 11 kPa, 35 kPa gels and on glass. Scale bars: 10 µm (overview), 2 µm (repesentative cells). (c) Cells spread on gels above 4.5 kPa. (c) Actin fibre alignment increased above 11 kPa. Data were pooled from one male and two female donors (28–54 years). See also Supplementary Fig. S15.