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. 2018 Apr 3;9:1293. doi: 10.1038/s41467-018-03650-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Uptake, protection, and release of ssDNA using MOFs as vectors. a Illustration of three critical processes in ssDNA transfection. b Uptake of ssDNA in Ni-IRMOF-74 samples (n = 3 technical replicates; bars represent mean ± s.d.). c Protection of ssDNA using various porous materials in FBS with 10% serum. Survived portion, residual left inside the vectors and digested portion of ssDNA are labeled in blue, yellow, and red, respectively. d Release of ssDNA from Ni-IRMOF-74 samples in the presence of cDNA (n = 3 technical replicates; bars represent mean ± s.d.). e X-ray absorption spectra of Ni-IRMOF-74-II before and after loading with ssDNA, blue and red, respectively. f Experiments that rule out the possibility of H-bond between ssDNA and MOFs. Ni-IRMOF-74 samples loaded with ssDNA were heated at 37 °C and 95 °C, red and blue, respectively (n = 3 technical replicates; bars represent mean ± s.d.). g Fluorescence quench of FAM-labeled ssDNA in contact with IRMOF-74-II and its components