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. 2018 Apr 3;8:5556. doi: 10.1038/s41598-018-23775-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Systems influence of osthole on pulmonary vascular remodeling. (A) H& E staining of rat lungs demonstrated that wall thickness was increased in the rats with PAH compared with healthy-control rats. (B) Deposition of collagen was obviously higher in the rats with PAH than that in healthy ones which was characterized by Masson staining. (C) Expression of α-SM actin was also markedly increased in the rats with PAH. These differences between PAH and control groups were considerably restored by osthole treatment (80 mg/kg/d). Data shows quantitative analyses of positive staining per vascular area. The data was denoted as mean ± S.E.M. (p value <0.05 was considered as statistically different between two groups (∗ or #), and p value < 0.01 (∗∗ or ##) was regarded as significantly different between two groups; *^, ** was indicated to compare with control group; ^{#, ##} was designed to compare with PAH group).