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. 2018 Apr 3;8:5556. doi: 10.1038/s41598-018-23775-8

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Experimental validation of typically differential proteins. (A) 60S ribosomal protein L15 (RPL15) expression in rats’ lungs. (B) Cathepsin S expression was expressed in rats’ lungs. (C) Histone H3.3 expression in rats’ lungs. (D) High mobility group box 1(HMGB1) expression in rats’ lungs. (p value <0.05 was considered as statistically different between two groups (∗ or #), and p value <0.01 (∗∗ or ^##) was regarded as significantly different between two groups; ^*,**was indicated to compare with control group; ^#,##was designed to compare with PAH group).