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. 2018 Apr 3;8:5506. doi: 10.1038/s41598-018-23901-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The adult rod bipolar cell transcriptome regulates synaptic structure and signalling. Gene ontologies and biological pathways involved in cell signalling and synaptic assembly are functionally enriched in the adult RBC transcriptome with p_adj ≤ 0.25. (a) Figure showing enriched gene ontologies cluster into 6 groups that share >50% of genes. Node size represents the statistical significance of enrichment and node shape corresponds to ontology source: circle = Gene ontology (GO) BiologicalProcess; diamond = GO CellularComponent; hexagon = Kyoto Encylopedia of Genes and Genomes (KEGG) pathway; octagon = REACTOME. (b) Table showing enriched gene ontologies and biological pathways in the adult RBC transcriptome, the corresponding gene names and the percentage (%) of the total number of genes in the adult RBC transcriptome associated with the Gene Ontology (GO) term. Colours correspond to functional groups in a. Genes selected for further investigation by immunolabelling/RT-PCR are in red.